Synthetic Human Polypeptide-62
INCI: SH-Polypeptide-62
Anti-aging peptide for skin repair
About Synthetic Human Polypeptide-62
Synthetic Human Polypeptide-62 (SH-Polypeptide-62) is a lab-engineered peptide that mimics naturally occurring proteins in human skin, specifically designed to accelerate cellular repair and combat visible signs of aging. Unlike traditional peptides that simply signal collagen production, SH-Polypeptide-62 works at a deeper level to support the skin's regenerative processes, making it particularly valuable in advanced K-beauty formulations focused on skin longevity. This ingredient has gained traction in premium Korean skincare because it offers the benefits of growth factor-like activity without the instability issues of naturally derived proteins. Its synthetic nature ensures consistency, purity, and a lower risk of immune reactions compared to animal or plant-derived alternatives. With a safety rating of 4 out of 5 and zero comedogenicity, it's suitable for most skin types, including acne-prone and sensitive complexions. You'll find SH-Polypeptide-62 in 13 products on Seoul Sister, often paired with other regenerative ingredients like PDRN (Polydeoxyribonucleotide) or EGF (Epidermal Growth Factor) in high-performing formulas such as Centellian24's CELLOLOGY Blue Eraser Cream and Anua's Zeroca 81 Serum, both rated 4.9 to 5.0 stars. The ingredient represents K-beauty's shift toward biotechnology-driven skincare that delivers measurable anti-aging results without harsh interventions.
How Synthetic Human Polypeptide-62 Works
SH-Polypeptide-62 functions by binding to specific receptors on skin cells, triggering a cascade of cellular responses that enhance repair mechanisms. At the molecular level, it stimulates fibroblasts (the cells responsible for producing collagen and elastin) to increase their activity, which helps restore structural integrity to aging or damaged skin. The peptide also supports the skin's natural protein synthesis pathways, essentially giving cells the signal to behave as they did in younger skin. Because it's synthetic, the amino acid sequence is precisely controlled to maximize receptor binding efficiency while minimizing the risk of degradation from environmental factors like UV exposure or pH fluctuations. This stability means the peptide remains active longer in formulations compared to naturally sourced proteins. Additionally, SH-Polypeptide-62 has been shown to support the extracellular matrix, the network of proteins and molecules that gives skin its firmness and resilience. By promoting both cellular turnover and structural support, this peptide addresses multiple aging pathways simultaneously, making it a comprehensive ingredient for maintaining skin health over time.
Synthetic Human Polypeptide-62 by Skin Type
Oily Skin
SH-Polypeptide-62 is ideal for oily skin because it's completely non-comedogenic and lightweight. It delivers anti-aging benefits without adding heaviness or clogging pores, making it perfect for those who want to address fine lines and texture while managing excess sebum. Products like VT's PDRN Reedle Shot Eye Lifter incorporate this peptide in formulas that absorb quickly without leaving a greasy residue.
Dry Skin
This peptide is highly beneficial for dry skin as it supports the skin's natural barrier repair processes and enhances moisture retention at the cellular level. By stimulating collagen production and improving the extracellular matrix, SH-Polypeptide-62 helps strengthen skin structure, which reduces transepidermal water loss. Look for it in hydrating formulas like Numbuzin's No. 9 NAD PDRN Glow Treatment Toner, which combines the peptide with humectants for maximum plumping effect.
Combo Skin
Combination skin thrives with SH-Polypeptide-62 because it provides targeted repair without disrupting the skin's natural balance. The peptide works on a cellular level, so it addresses aging concerns in drier areas while remaining non-greasy enough for oilier zones. Its versatility makes it a staple in well-formulated K-beauty serums like Anua's Zeroca 81 Serum, which adapts to different areas of the face.
Sensitive Skin
With a strong safety profile and synthetic purity, SH-Polypeptide-62 is generally well-tolerated by sensitive skin. Because it's lab-created rather than derived from potentially allergenic plant or animal sources, it minimizes the risk of immune reactions. However, sensitive skin should still patch-test products and introduce peptides gradually, especially when combined with active ingredients like retinol or acids.
Normal Skin
Normal skin can use SH-Polypeptide-62 as a preventative anti-aging measure, maintaining optimal cellular function before significant damage occurs. It's an excellent choice for those in their late twenties or early thirties who want to preserve skin quality. The peptide works synergistically with other ingredients, making it perfect for layering in comprehensive routines featuring products like Franz's Naked Sunshield EGF Patch for targeted treatment.
How to Use Synthetic Human Polypeptide-62
- 1Apply SH-Polypeptide-62 products to clean, slightly damp skin so the peptide can penetrate more effectively. Serums and toners containing this ingredient work best when used before heavier creams or oils.
- 2For maximum efficacy, use peptide products consistently for at least 8-12 weeks. Peptides work gradually by signaling cellular changes, so results are cumulative rather than immediate.
- 3Store peptide-containing products away from direct sunlight and extreme temperatures. While SH-Polypeptide-62 is more stable than natural proteins, heat and light can still degrade its effectiveness over time.
- 4Layer with other anti-aging ingredients like niacinamide, hyaluronic acid, or PDRN for synergistic benefits, but introduce new actives one at a time to monitor skin response. Avoid using peptides with high-concentration AHAs or retinol in the same application, as low pH environments may reduce peptide activity.
Background
Synthetic peptides emerged in skincare in the early 2000s as biotechnology advanced enough to create stable, lab-engineered versions of proteins found naturally in human skin. SH-Polypeptide-62 specifically was developed as part of the broader movement toward biomimetic ingredients, substances that replicate biological functions without relying on animal or plant extraction. Korean skincare brands were early adopters of synthetic peptide technology, recognizing its potential for delivering clinical-level results in cosmetic formulations. The "SH" designation indicates it's a synthetic human-derived sequence, meaning its structure mirrors peptides naturally present in human tissue. This approach allows for greater purity and consistency compared to older peptide technologies that relied on botanical or animal sources, which often came with stability and ethical concerns. K-beauty's focus on innovation and science-backed ingredients helped popularize synthetic peptides globally, positioning them as accessible alternatives to more invasive anti-aging treatments.
K-Beauty Products with Synthetic Human Polypeptide-62
View all 13 →
CELLOLOGY Blue Eraser Cream
Centellian24
Naked Sunshield EGF Patch
Franz
Zeroca 81 Serum
Anua
PDRN Reedle Shot Eye Lifter
VT
No. 9 NAD PDRN Glow Treatment Toner
Numbuzin
No. 9 NAD RetinA Volume Shot Eye Cream
Numbuzin
Silk Peptide EGF Heart Fit Volume Lifting Ampoule
Sungboon Editor
No. 9 NAD Bio Lifting-sil Full Face Pack Sheet 4ea Set
Numbuzin
Reedle Shot Synergy Repair Cream EX Plus
VT
No. 9 NAD Collagen Overnight Selfie Patch
Numbuzin
Curepair Mela Cream Set
Centellian24
PDRN Moist Tone Up Sun Essence
VT
Frequently Asked Questions
Is SH-Polypeptide-62 the same as EGF or PDRN?▼
Can I use SH-Polypeptide-62 with retinol or vitamin C?▼
How quickly will I see results from SH-Polypeptide-62?▼
Is this ingredient safe during pregnancy or breastfeeding?▼
Why is SH-Polypeptide-62 more expensive than other anti-aging ingredients?▼
Explore More
Want personalized ingredient advice?
Yuri, our AI beauty advisor, can analyze how Synthetic Human Polypeptide-62 works with your specific skin type, routine, and concerns.
Try Seoul Sister Pro